Vol. 6, Issue 1, Part A (2024)

Impaired memory and cognitive function are the main features of Alzheimer’s disease (AD). Unfortunately, currently available treatments cannot cure or delay AD progression. Moreover, the blood-brain barrier hampers effective delivery of treatment to the brain. Therefore, we aimed to evaluate the impact of hydroalcoholic extract of ginko biloba and cicurium intybus as protective compound from neurodegenerative effect of Alzheimer disease in rat. Forty male rats were divided into five groups (eight rats each), being: C-: control negative (received 1 ml of distilled water), C+: aluminum chloride (AlCl3) (100 mg/kg, p.v.) for 28 days (positive control), G: Ginkgo Biloba (120 mg/kg, p.o.) one hour before the induction of Alzheimer's with AlCl3 (100 mg/kg.b.w.) for 28 days, C: Cicurium intybus (500 mg/kg.bw p.o) one hour before the induction of Alzheimer's with AlCl3 (100 mg/kg. bw) for 28 days and G+C: combination of GB + CI one hour before Alzheimer's induction with AlCl3. The result of neurobehavioral tests revealed that drenched of 100mg/kb.bw of Alcl3 significant decrease (p>0.05) the number of squares crossed by four legs /3 minutes, swimming test and Y-maze test in all treated groups as compared with control negative group. However, the tau protein overexpressed in control positive group as compared with protective groups. Histopathological slides note there were a necrosis, hemorrhage with the presence of inflammatory cells in the subiculum area of the hippocampus in brain of control positive group while the best protective effect showed in combination group. In conclusion, the combination of two antioxidant herbs is an effective, safe, and non-invasive approach with superior cognitive function capabilities compared to each one alone.