Vol. 7, Issue 1, Part B (2025)

Background: Multiple sclerosis (MS) is a chronic inflammatory disease that is degenerative and demyelinating affected central nervous system. Magnetic resonance (MR) remains primary method for monitoring clinical evolution and therapeutic response of these cases. The study aimed to evaluate relation between cerebral perfusion and clinical severity of MS.
Methods: This cross sectional study was done on 50 cases at MS Unit at Department of Neuro Psychiatry, Centre of Psychiatry, Neurology and Neuro Surgery, Tanta University Hospitals, Egypt. All cases were subjected to full neurological examination and multiple sclerosis special tests including assessment of enhanced disability status scale (EDSS), 9-hole peg test.
Results: The mean transit time (MTT) and EDSS exhibited a significant positive correlation (r=0.667, P <0.001) in both normal appearing grey matter (NAGM) and normal appearing white matter (NAWM) (r=0.670, P<0.001). Conversely, the cerebral blood flow (CBF) and cerebral blood volume (CBV) of NAGM (r=-0.760, P<0.001) and NAWM (r=-0.781, P<0.001) exhibited a significant negative correlation (r=-0.808, P<0.001) and NAWM (r=-0.849, P<0.001).
Conclusion: We found a negative correlation among disability parameters (EDSS, 25 Foot walk, 9 Peg hole) and CBF in various GM amd WM regions, confirming that physical disability severity is related to brain hypoperfusion. Particularly, brain hypoperfusion and prolonged transit time were associated with an increase in EDSS, 25-foot walk, and 9-peg hole in numerous GM and WM.